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Because the human trials looked at markers such as insulin sensitivity and GLP-1, it is not something to add casually on top of medication that acts on the same system

For patients whose smile has changed significantly due to facial volume loss, smile design can be coordinated with facial aesthetic treatments (such as dermal fillers for lip and cheek support) for a fully integrated outcome

More recent work has examined boron-rich derivatives (PMID 30168238) and PET-imaging-relevant peptidomimetic derivatives (PMID 30282322), broadening the SAR landscape around the original compound