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Common reasons for an imbalanced ratio between phosphatidylcholine and cholesterol include: Fasting Overeating High-fat diet Ketogenic diet Vegan diets Protein deficiency Low dietary choline intake Low dietary glycine intake Methylation disregulation Dirty MTHFR Dirty PEMT Dehydration Low stomach acid Ongoing intake of proton pump inhibitors (PPIs) Bacterial overgrowth of specific bacteria such as certain Clostridia species What Happens When You Dont Have Healthy Bile Composition or Bile Flow

If youve been taking higher doses to achieve weight loss, you may need some time to gradually lower doses until you can stop

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However, individual responses vary considerably and require close monitoring

Available from: Knop FK, et al

Lets look at what the research shows about outcomes and timelines