The first month is structured because thats when the dose is set and any side effects show up
Janney MS, Subramaniyan R, Dabas R, Lal S, Das NM, Godara SK
Inhibition of the target gene expression can occur through various mechanisms such as RNA interference, once the sense-antisense mRNA duplex has formed, transcriptional interference, in which the NAT can act as a physical barrier for RNA polymerase activity, or epigenetic methylation of the sense gene DNA, thus inhibiting the transcription of the sense mRNA transcript [55, 56]
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Although clinical translation remains in its early stages, the gut-brain axis represents a promising, non-invasive, and systems-level target for neuroprotection