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170,171,172,173 Therapeutic implications for targeting NADPH metabolism Compared with their normal counterparts, many types of cancer cell have increased oxidative stress and the upregulation of antioxidant capacity

doi: 10.1097/HJH.0b013e3282fd9936 113

50 and analyzed by LC tandem MS (TSQ Altis, Thermo Scientific) as previously described 11

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For these reasons, precursors of GSH have been investigated

D-GalN, LPS and TNF- were purchased from Sigma-Aldrich