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Those conditions include rapid dose escalation of bupropion, concurrent use of medications that lower the seizure threshold, eating disorders with purging behavior, alcohol withdrawal, and critically for our discussion, dehydration and electrolyte imbalances

During the preceding titration phase, there were more additional follow-ups during semaglutide use because of several reasons, such as increased adverse events and the need for additional glycemic reviews for safety, although these additional follow-ups were predominantly accounted for by a minority of participants who were using open-loop pump therapy (Supplementary Table 3)