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We have recently reported downregulation of the expression of UCPs 2 and 4 in the parahippocampal gyrus of AD brains where GMF expression is also increased (Thangavel et al., 2017)

Providing a treatment option that is proven to lower this cardiovascular risk is a major advance for public health. The FDAs decision is largely based on data from the SELECT trial, which included more than 17,000 overweight or obese patients with a baseline age of 45 years old