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Further controlled human studies are necessary to clarify safety parameters, long term outcomes, and any potential translational relevance within clinical research frameworks

B12 Injections: Pros and Cons Injections deliver B12 directly into the muscle, where it is absorbed rapidly into the bloodstream

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Cell Rep 22(3):569575

RGN-352 was shown to be safe and well-tolerated with no serious drug-related adverse events reported (PMID: 20536472) Phase 2 AMI trial (incomplete): RegeneRx designed a Phase 2 proof-of-concept trial (NCT01311518) to evaluate RGN-352 in approximately 75 patients with acute ST-segment elevation myocardial infarction (heart attack)

Peptides that promote tendon fibroblast activity and collagen reorganization are particularly relevant here