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Parallelly, increased intracellular calcium concentration activates calcium/calmodulin-dependent protein kinase II (CaMKII), downregulating Caspase-3 expression and subsequently inhibiting apoptosis in ovarian granulosa cells (121)

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The researchers also found evidences that overexpression of catalase and rapamycin together reduced angiogenesis

Moreover, INS-1 cells were transfected with si-PARP-1 in the presence or absence of LXR receptor agonist T0901317, and the expression and protein levels of ABCA1 were examined