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The blood-tumor barrier is characterized by higher permeability to small molecules, although a large majority of drug therapies are still unable to penetrate the CNS in adequate concentration because of their large size and transport mechanisms, such as Pgp, that shuttle drug away from the brain

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Whereas saturated to unsaturated fatty acid ratio in the cholesteryl esters from LDL and HDL diminished, in contrast, this ratio rose in VLDL particle

Immunohistochemistry images revealed a clear increase in GLUT1 expression in both the ileum and colon of metformin-treated mice (Fig