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Modulating CHAC1 activity could enhance cancer cell susceptibility to ferroptosis, overcoming resistance to conventional therapies

The renal or extrarenal expression of 1--hydroxylase (CYP27B1) enzymatic action converts 25(OH)VD 3 to an active metabolite 1,25-dihydroxy vitamin D 3 (1,25(OH) 2 VD 3) 13

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Classical fractionation studies described high GR activities in chloroplasts (Foyer and Halliwell, 1976) but GR has also been detected in the cytosol, mitochondria, and peroxisomes (Edwards et al., 1990

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