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While theyre fundamentally similar medications, they differ slightly in their mechanism of action: Wegovy (semaglutide) is a GLP-1 agonist Zepbound (tirzepatide) is a dual agonist: GLP-1 + a glucose-dependent insulinotropic polypeptide (GIP) Both semaglutide and tirzepatide affect the hypothalamus and the hedonic eating centers, the brains center of appetite and cravings

[16] [17] Review your medicines: If you are taking orlistat, metformin, or magnesium-containing supplements, discuss with your GP or pharmacist whether these could be contributing to loose stools

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doi: 10.1128/AEM.02542-10 [DOI] [PMC free article] [PubMed] [Google Scholar] 66.Kwon DH, Alsaleh S, Alharbi F, Almansour A

Pre-injection preparation techniques include: Cleaning the injection site with an alcohol swab and allowing it to dry completely (wet alcohol can cause stinging and tissue irritation) Refraining from rubbing or massaging the injection site before or immediately after injection Using standard 4-mm, 32G pen needles, which minimize tissue trauma for most patients Applying firm pressure (without rubbing) with a clean gauze pad or cotton ball for at least 2 minutes after needle withdrawal, especially for patients on blood thinners For patients taking anticoagulants or antiplatelet medications, do not change your medication dosing or timing for injections