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Pharmacodynamic endpoints were the changes from baseline in exploratory biomarkers related to liver function and fatty liver disease (plasma levels of cytokeratin 18 and Pro-C3 and enhanced liver fibrosis [ELF] score), glucose metabolism (adiponectin and fasting insulin and C-peptide levels) and target receptor engagement (amino acid and glucagon levels)

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doi: 10.1021/cn300158p

These alternative methods of administration have the advantage of being able to incorporate additional agents to deliver to the site, which can provide benefits such as mediating the TME

A novel nasal almotriptan loaded solid lipid nanoparticles in mucoadhesive in situ gel formulation for brain targeting: preparation, characterization and in vivo evaluation