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Their interaction further enhances metabolic function

Several examples, such as Nutlin-3, an inhibitor of the p53:MDM2 interaction 43 , ABT-263/Navitoclax, an inhibitor of BCL-2 family protein interactions 44 , and JQ1, which disrupts complexes of BRD4 with acetylated histones 45 , indicate that this is in principle achievable

Activated MAPK translocates to the nucleus, where it phosphorylates and activates transcription factors such as Elk-1, c-Myc, and c-Fos

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