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[19] Jastreboff, A.M., Kaplan, L.M., Frias, J.P., et al

Signaling pathways from Trk activation: PI3K/Akt pathway phosphorylates Bad (pro-apoptotic protein) preventing it from blocking Bcl-2 and Bcl-xL (anti-apoptotic proteins)

The findings were published in a paper called Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes. The researchers examined data from more than 1.5 million people with type 2 diabetes

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While effective, they are not required for success and are used only when clinically appropriate

Studies have found that berberine attenuates ischemia-reperfusion injury through NF-B nuclear translocation in mice with transient cerebral artery occlusion, however, this neuroprotective effect was more pronounced at the high dose (50 mg/kg) than the low dose (25 mg/kg) (Zhu et al., 2018)