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The binding of GLP-1 (or semaglutide) to GLP-1 receptors activates several biological responses: Increased insulin secretion after food intake, which improves blood glucose levels Reduced glucagon secretion, which limits glucose in the blood and helps reduce spikes in blood sugar Slowed emptying of the stomach, which helps people feel less hungry during the day Suppressed appetite, which again helps with feelings of satiety All of these factors promote sustained food (and therefore calorie) reduction, supporting weight loss with time

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It's also a boon for weight loss, since excess blood glucose gets stored as fat

Potential treatments are generally divided into two large categories: disease modifying therapies and symptomatic treatments

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