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These results suggested that keloid fibroblasts underwent pro-senescence regulation earlier compared with normal skin fibroblasts via p53-pS15 under serum limitation stimulus, and p53-pS15 and FOXO4 translocated from the nucleus to the cytoplasm during FOXO4-DRI treatment

To his knowledge, "it was the first time a vegetable was commercially grown solely to deliver a health benefit." Although the team worked with a nationwide network of local growers and packers, the challenges of broccoli sproutstheir exceptionally short shelf life especiallyproved too much to overcome, and by the early 2000s, the company switched to selling extract

They use another protein, FOXO4, to keep p53 stuck in the nucleus so it cannot trigger cell death

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Zoppi F, Brenna S, Fumagalli C, Marocchi A