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- **Underlying conditions**: Documentation must reflect the chronic disease causing the anemia (e.g., chronic kidney disease, heart failure, or other chronic diseases classified under compendia support)

While some patients may experience initial side effects such as nausea or diarrhea, these are generally manageable and tend to decrease over time

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Current data suggests that the relevance of targeting MC1R mediated pathways may depend on receptor expression levels and genetic background, emphasizing the need for continued research to clarify the receptors protective roles within epidermal layer biology

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