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However, subsequent salvage therapy with bevacizumab and continuation of the KD led to a response in six out of seven patients, and the authors confirmed in a mouse experiment that the combination of KD and bevacizumab, but not the KD alone, was superior to bevacizumab combined with standard chow with respect to survival and tumor size

These symptoms tend to happen more at the start of treatment or when the dose is increased

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PubMed Jastreboff, A.M., Aronne, L.J., Ahmad, N.N., Wharton, S., Connery, L., Alves, B., et al

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Cell 166: 140151 Iraqui I, Kienda G, Soeur J, Faye G, Baldacci G, Kolodner RD, Huang ME (2009) Peroxiredoxin Tsa1 is the key peroxidase suppressing genome instability and protecting against cell death in Saccharomyces cerevisiae