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In the absence of a substantial reduction in ATP demand, cardiomyocytes compensate by upregulating glucose uptake and the expression of key glycolytic enzymes, thereby relying on glycolysis as an alternative energy source to maintain basic cellular functions

Semaglutide might be better for those concerned about cost, side effects, or underlying metabolic conditions, given its longer real-world data and gentler side effect profile

doi: 10.1038/s41467-021-23111-1 113 GuerreiroR.WojtasA.BrasJ.CarrasquilloM.RogaevaE.MajounieE.et al

2023: The year in cardiovascular disease - the year of new and prospective lipid lowering therapies

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Mice that received GLP-1MK-801 on top of semaglutide displayed potentiated weight loss compared with mice that were co-treated with semaglutide and GLP-1 (Fig