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The New England Journal of Medicine

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These include: Nasal congestion Some people report nasal stuffiness while taking semaglutide, which could make allergic rhinitis feel worse

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Injections Boost metabolism and energy

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Metabolic Health & Insulin Sensitivity Modulation of NNMT activity has been associated with improved glucose handling and insulin sensitivity, suggesting potential benefits in metabolic syndrome and related conditions

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The potential value of combining these therapies lies in addressing overlapping cardiorenal and metabolic risk pathways as available evidence for dual therapy in HF populations remains limited and is derived largely from subgroup analyses, observational studies, and extrapolation from diabetes or obesity trials rather than dedicated HF randomized trials [24, 25, 27, 30, 50]

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[DOI] [PubMed] [Google Scholar] Wang X, Zhou J, Doyle ME, Egan JM

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