Patients should check with their healthcare provider about local availability
10.1038/s41585-018-0117-7 100 TwidwellJ.LevineL
This shows a powerful truth about medicine: A molecule can have a story far bigger than its first purpose
After maturation, MSTN is expressed in various tissues,[12,20,21] with the highest levels in skeletal muscle and lower levels in visceral and subcutaneous fat,[21] as well as cardiac muscle.[20] MSTN has also been reported to negatively regulate adipocyte differentiation and lipid accumulation by suppressing the expression of key transcription factors such as peroxisome proliferator-activated receptor (PPAR-) and CCAAT/enhancer binding protein-.[22] However, Mstn / mice exhibit significantly reduced fat accumulation under normal aging conditions despite a lower metabolic rate, [23] whereas a genetically obese mouse model shows elevated MSTN mRNA levels compared to wild-type mice, suggesting a positive correlation between MSTN expression and fat mass.[21] These findings have paved the way for MSTN to become a therapeutic target not only for muscle atrophy, but also for diabetes and obesity
The present study provided direct laboratory evidence supporting the antitumor effects of GLP-1R antagonism in CRC, as opposed to agonism
Effect of Pomegranate Extract Consumption on Satiety Parameters in Healthy Volunteers: A Preliminary Randomized Study
