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What are the differences in how semaglutide and tirzepatide are administered

Baseline muscle mass, pre-existing nutritional deficiencies, and concurrent medical conditions such as diabetes or inflammatory diseases can also affect muscle preservation during semaglutide therapy

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Acute Kidney Injury Acute kidney injury occurred in clinical trials for weight reduction in 7 adult patients (0.4 cases per 100 patient years) receiving WEGOVY versus 4 patients (0.2 cases per 100 patient years of exposure) receiving placebo

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For type 2 diabetes, semaglutide is initiated at 0.25 mg subcutaneously once weekly for four weeks, then increased to 0.5 mg weekly