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doi: 10.1021/acs.jmedchem.2c01856 212 SiegelCHSammaritanoLR

In mammalian cells, the helicase DDX21 recruits the METTL3/14 complex to R-loops, promoting proper termination and safeguarding genome stabilitydirect evidence that functionally links m 6 A writing to transcriptional mechanics ( 6 A -tagged transcripts through SRSF3NXF1 and related adaptors, and YTHDC1-driven condensates can gate export under disease conditionsunderscoring the idea that nuclear m 6 A recognition programs downstream cytoplasmic fates ( In the cytoplasm, YTHDF paralogs generally bias marked mRNAs toward CCR4NOT-coupled deadenylation and decaya unified model supported by loss-of-function genetics and quantitative transcriptomics

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