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This activates protein kinase A (PKA), which phosphorylates and stabilizes MITF (microphthalmia-associated transcription factor), driving transcriptional upregulation of tyrosinase, TRP-1, and TRP-2rate-limiting enzymes in the eumelanin biosynthesis pathway (Abdel-Malek et al., Pigment Cell Research, 2001)

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Krivic et al., 2008) ligament-healing (Cerovecki et al., 2010) and has a strong osteogenic effect the in non-union model (Sebecic et al., 1999) (and in other models, such as is observed with rat femoral head osteonecrosis (Gamulin et al., 2013), or alveolar bone loss (Keremi et al., 2009)

However cells treated with DEM 100 M showed a very low growing profile