Common gastrointestinal side effects include nausea, diarrhoea, vomiting, and abdominal discomfort, particularly during treatment initiation
Loss of appetite is listed separately as common and dose-dependent, usually appearing within the first week
Retatrutide's Phase 2 numbers sit above both, though it is essential to note that direct cross-trial comparisons are methodologically imperfect due to differences in population, duration, and titration protocols
Appetite Suppression Semaglutide works by slowing gastric emptying, which helps to reduce appetite and caloric intake
Kidney Problems: Dehydration from nausea, vomiting, or diarrhea can sometimes affect kidney function
The minimum threshold for hair protection during weight loss appears to be around 1.0-1.2 grams of protein per kilogram of body weight daily, with some researchers recommending 1.2-1.6 grams per kilogram for those losing weight aggressively