One prime example is the discovery of the nutrient sensing mechanism for cholesterol, which led to the development of life-saving statin drugs (and the Nobel Prize)
Later questions revealed that NIH does not post notices of submissions received late or not at all, and no penalties have been assessed to responsible parties
5.7 Vitamin B12 Concentrations In controlled clinical trials of metformin of 29-week duration, a decrease to subnormal levels of previously normal serum vitamin B12 levels, without clinical manifestations, was observed in approximately 7% of patients
For someone with a diagnosed deficiency, 3000 mcg may sometimes be used temporarily
Blood work & diagnostic testing (if necessary)
In this context it is important to note, that the direct influence of L-Carnitine on tumor growth has not been measured in this study and is beyond the scope of this work