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These data raise the possibility that supplementing glucagon-like peptide-1 receptor agonist treatment with GDF8 and activin A blockade could greatly improve the quality of weight loss during the treatment of obesity in humans

doi: 10.3389/fimmu.2026.1793440 Received 22 January 2026 Revised 25 February 2026 Accepted 06 March 2026 Published 23 March 2026 Volume 17 - 2026 Edited by Baocun Zhang, Aarhus University, Denmark Reviewed by Yibo Ma, Second Affiliated Hospital of Dalian Medical University, China Daniela Poenaru, Carol Davila University of Medicine and Pharmacy, Romania Updates Copyright 2026 Chen, Gao, Luo, Wang, Niken, Xu, Ding and Guo

Still, timing matters

Future research is needed to better understand ongoing central oxidative stress processes in relation to peripheral mechanisms, and how these mediators change across the course of disease in people with PTSD

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Nat Rev Dis Primers 3:17016