[19] This finding matters for women navigating perimenopause and menopause, when muscle preservation becomes increasingly difficult
0.33g of the crude Boc-His (Trt) -Aib-OSu and 1g of the compound 2 obtained in example 2 were dissolved in 20mL of N, N-dimethylformamide, and 2mL of N, N-diisopropylethylamine was added and reacted at room temperature for 8 hours to obtain compound 4 having a purity of 76.13%, and a specific liquid phase diagram is shown in FIG
et la chane latrale de Lys 26 est prpare par synthse fragmentaire, et un fragment entirement protg de Fmoc-PEG-PEG--Glu-acide octadcanedioque utilis dans la synthse fragmentaire de la chane latrale de Lys 26 est prpar par le couplage successif d'une rsine de chlorure du Fmoc-PEG-OH, du Fmoc-PEG-OH, du Fmoc-Glu(OH)-OtBu et un ester mono-tert-buytlique d'acide octadcanedioque, clivage et recristallisation pour obtenir un PEG-PEG--Glu-ester mono-tert-butylique d'acide acide octadcanedioque
Fmoc-Gly-2-CTC-Resin with a degree of substitution of 0.535 mmol/g was obtained, following washing 3 times with DMF, shrinking twice with methanol, and drying under reduced pressure
Pharmacokinetic properties: The pharmacokinetic properties of semaglutide include absorption, distribution, metabolism and excretion
Example 14: Synthesis of peptide resin of Semaglutide [0078] The Fmoc-Gly-2-CTC resin synthesized in Example 6 was used for the synthesis of peptide resin of Semaglutide
