The pivotal SURMOUNT-1 demonstrated mean weight reductions of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) at 72 weeks, with 36% of patients on the highest dose achieving 25% or more weight loss
Similarly, bruising that occurs spontaneously without any apparent trauma or injection should be investigated, as it may suggest an underlying bleeding disorder or medication interaction
That differs from prescription GLP-1 receptor agonists, which change gut-brain hormone signaling and alter appetite regulation centrally
GLP-1 receptors influence gastric motility, satiety, and insulin secretionall processes that interact with thyroid hormone levels and replacement dosing
When stored as a dry powder , peptides remain stable for up to 2 years
A 2022 review in the Journal of Clinical and Aesthetic Dermatology noted that dermatological adverse events, while relatively uncommon, represent an important consideration in GLP-1 agonist therapy