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In homozygotes, microglial and astrocyte activation appeared at 12 months, neuronal loss in the hippocampus and entorhinal cortex at 24 months, and synaptic loss at 8 months

Toxicology and applied pharmacology, 23(1), 5461.

10.1016/j.neuroscience.2007.08.028 [DOI] [PubMed] [Google Scholar] 52.Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J

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Deposition of harmful protein aggregates in neuronal cells causes age-related neurodegenerative diseases such as Alzheimers disease and Parkinsons disease, which damage cognitive ability and memory loss (Sonawane et al., 2021)

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