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In contrast, when tissue folate or cobalamin stores are intact (Silberberg et al, 1997) or in the case of an alteration of the transsulfuration pathway dependent on vitamin B 6 deficiency or on heterozygosity for a CBS defect (Bostom et al, 1995a), an excessive methionine supply might lead to an important elevation of plasma homocysteine

A4: Results may vary

209 Generally, APC mutations and classic mutations of -catenin are more common in CRC, 210,211 gastric cancer (GC), and endometrial carcinoma, 212 while AXIN mutations primarily occur in hepatocellular carcinoma (HCC) 213 and medulloblastoma with dysfunction of the Wnt pathway

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