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17,18 Dysregulation of the hypothalamic-pituitary-ovarian axis by hyperandrogenism increases gonadotropin-releasing hormone pulse frequency and is associated with the increased ratio of luteinizing hormone to follicle-stimulating hormone observed in PCOS

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At baseline, CV disease and risk factors were managed with lipid-lowering therapy (90%), platelet aggregation inhibitors (86%), angiotensin converting enzyme inhibitors or angiotensin II receptor blockers (74%), and beta blockers (70%)