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Bataille D, Chan SL, Delagrange P, Drucker DJ, Gke B, Hills R, Mayo KE, Miller LJ, Salvatori R, Thorens B

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Indeed, besides a familial component in insulin resistance, as in general population, patients with PWS have fairly low fasting insulin concentrations and a lower incidence of insulin resistance compared to that expected considering the body mass index (BMI), probably due to a greater distribution of adipose tissue in the subcutaneous than in visceral site [15, 29, 30]

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And they understand that medication is one tool in a broader, medically supervised program