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It was found that, as in the case of other xenobiotics, Ca 2+ influx plays an extremely important role in chromium (VI)-dependent toxicity [184]

Y., et al., Synthesis and Evaluation of 1Phenyl1H1,2,3Triazole4Carboxylic Acid Derivatives as Xanthine Oxidase Inhibitors, Bioorganic & Medicinal Chemistry Letters 27 (2017): 38123816, 10.1016/j.bmcl.2017.06.059

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This observation supports the hypothesis that ferroptosis, a type of nonapoptotic cell death, has a greater possibility of inducing inflammation than apoptosis

Last reviewed: July 17, 2026 Last updated: July 17, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations