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Once in the cytosol, the mature toxin forms a complex with preprotoxin molecules that have not yet been imported into the ER, which can be ubiquitinated and then proteasomally degraded, protecting the cell from the lethal effects of the -subunit

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doi: 10.1111/j.1600-065X.2008.00628.x 31 ManhartNVierlingerKSpittlerABergmeisterHSautnerTRothE

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The first seven trials involved patients with T2DM and baseline glycated hemoglobin levels ranging from 7.3 to 8.7, whereas the most recent SELECT trial focused on nondiabetic patients with overweight or obesity and preexisting cardiovascular disease

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