The pharmacological profiling indicated that, like GHRP-6, ipamorelin stimulates GH release through a GHRP-like receptor [3, 4]
Also, it promotes less storage of fat in the liver
One directly affects the somatotropic cells of the anterior pituitary, itself inhibiting further release of GH, whilst the other affects GH releasing hormone and somatostatin release from the hypothalamus to reduce the secretion of GH
Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE
When Sermorelin binds to GHRHR, it causes a conformational change that activates coupled Gs proteins, which stimulate adenylyl cyclase to catalyze conversion of ATP to cyclic AMP (cAMP)
Acanthopagrus Schlegelii 503, 389395