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Characterization of the surface immobilized synthetic heparin binding domain derived from human fibroblast growth factor-2 and its effect on osteoblast differentiation

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Numerous studies have confirmed the critical importance of irregular HGF/c-MET signaling in promoting growth, invasion, metastasis, apoptosis resistance, initiation of epithelial-mesenchymal transition (EMT), and enhancement of angiogenesis [7,8,9,10] (Fig