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Nevertheless, the directional outcome was clear: tirzepatide demonstrated numerically higher weight loss at every analysis point, and the non-inferiority margin was not met

Furthermore, developing small molecule inhibitors targeting BCAA transporters in tumor cells and immunosuppressive cells allows CD8 + T cells to obtain amino acid metabolic advantages in the immune microenvironment and enhance the anti-tumor effect

This combination creates unique challenges for both diagnosis and treatment

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