doi: 10.1056/NEJMoa1614949 22 VendittiPBalestriniMDi MeoSDe LeoT
Positive regulators of melanin production include endothelins, histamine, and eicosanoids, which act through cell surface receptors
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Patients often report reduced hunger, smaller meal sizes, fewer cravings, and lower overall caloric intake
Our review of all the reported cases consistently displayed a female predominance (male:female=1:2.98), and when excluding black populations, female predominance was even more pronounced (male:female=1:6.23)
Inoue A, Kikuchi S, Hishiki A et al (2014) A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin