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The concentration of -Syn in the CSF of PD patients was remarkably lower than that of normal participants, with the diagnostic sensitivity and specificity of 53.5 and 76.8%, respectively (Shi et al., 2014)

Additionally, E2 is known to be able to signal through the insulin-like growth factor 1 receptor (IGF-1R) in the skin in a non-genomic manner and this process has been implicated in the regulation of cutaneous aging (Emmerson and Hardman, 2012)

4.6 Parkinsons disease Parkinsons disease (PD) is a rapidly progressive neurodegenerative disorder for which effective disease-modifying therapies are lacking

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Effective biomarkers, such as GPX4, 4-HNE, and MDA in joint fluid, can be used to monitor treatment response and assist in dose optimization (Table 2)

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