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In 1996, when the survey was repeated again in the same area, awareness and use of oral vitamin B12 for pernicious anemia had increased substantially (019%), but the majority of doctors still remain unaware of this treatment option (61%) (8)

These temporal patterns highlight a critical window for intervention between 3-6 months post-infection, when IBS symptoms often become established yet remain potentially reversible before chronic remodeling occurs

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It also serves as a substrate for various antioxidant enzymes, including glutathione peroxidase and glutathione reductase, which further amplify its protective effects