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Expert Opin Ther Targets (2012) 16(11):1097112

Standard Dosing Parameters Primary Application Dosing 1-2 mg daily 2-3 mg daily or 2 mg 2-3x per week 1-2 mg daily (injectable or topical) 2-5 mg daily under medical supervision Clinical studies used 0.3 mg/mL injections, while systemic wound healing in animal studies used approximately 1.1 mg/kg body weight (translating to ~75 mg total for humans in divided doses)

doi: 10.9734/BJPR/2017/32843 230 PeroniDGHufnaglKComberiatiPRoth-WalterF

A higher proportion reached clinically meaningful weight-loss thresholds, with greater improvements in cardiometabolic markers

That enzyme simply doesn't act on it

Food supplements should not replace a balanced diet