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[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Christensen MB, Filip K

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Research demonstrates that postmenopausal women experience a 9% decrease in total 24-hour energy expenditure and a 30% reduction in spontaneous physical activity energy expenditure.[1] The metabolic consequences are profound: estrogen deficiency worsens insulin resistance, which is further exacerbated by the age-related increase in cortisol that promotes gluconeogenesis

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Post-marketing surveillance and clinical data suggest the risk remains low, though individuals with a personal or family history of pancreatitis face elevated concern