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Lipoxin A4 ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the esr2/lpar3/nrf2 axis in synovial fibroblast-like synoviocytes

2 Since SLC25A39 protein is expressed in various tissues including the postnatal brain (see for details e.g.,: this may hint for a specific role of that carrier in mitochondrial activity of certain neuronal populations

Once PUFA-containing phospholipids become integrated into cell membranes, they are highly susceptible to peroxidation

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Additionally, ROS-modulated gene expression increases endothelial permeability, inflammation, and vascular disease by affecting T-cell polarization and cytokine secretion [34]