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In laboratory settings, 5-Amino-1MQ has been studied for its ability to reduce NNMT-mediated methylation of nicotinamide, which influences the availability of methyl groups and the cellular NAD+ pool

Benson J, et al

Neural Regeneration Research, 15(11), 2097-2104

Cardiac research has examined TB-500's effects on heart tissue repair and remodeling following injury

Especially for those who suffer from stomach difficulties such as pernicious anemia or inflammatory bowel disease, B12 injections are a preferred choice as they bypass potential absorption issues

I guess it depends on how low each persons individual levels are and how quickly they utilise the B12