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While clinical trials confirm curcumins safety and efficacy at appropriate dosages for various human and animal diseases, its clinical utility is hindered by poor bioavailability due to limited absorption and rapid metabolism

Additionally, the APOL1 gene may interact with other genes to cause kidney disease

A consistent finding is reduced overall microbial diversity in AD, along with a phylum-level shift: the proportion of Firmicutes (typically beneficial fiber-degrading bacteria) tends to be decreased, while Bacteroidetes are increased [124]

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