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For histology, the left hepatic lobe was enclosed in a prelabelled histology cassette and fixed in 10% neutral buffered formalin for 24 h, followed by 70% ethanol for another 24 h before submission for tissue processing

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84-86 In a randomized placebo-controlled trial with 120 participants in perimenopause or early postmenopause, daily treatment with 500 mg hops, providing 100 mcg of phytoestrogens, for 12 weeks reduced the number of hot flashes and overall symptom scores