10.1016/j.ijbiomac.2020.07.168 151 NaikS.BouladouxN.WilhelmC.MolloyM
N.EmterR.HockM
Additionally, chronic conditions such as HIV and tuberculosis have been implicated in B12 deficiency due to increased metabolic demand and altered absorption mechanisms ( The diagnosis of vitamin B12 deficiency typically relies on low total B12 levels and elevated concentrations of homocysteine (Hcy), as well as levels of transcobalamin-bound B12 (holoTC) and methylmalonic acid (MMA), which serve as functional indicators of cobalamin insufficiency ( Vitamin B12 requirements fluctuate throughout the life course, influenced by metabolic demand and physiological changes
doi: 10.1056/NEJMOA1503734 266 OlsenSFsterdalMLSalvigJDMortensenLMRytterDSecherNJet al
By using patch-clamp, we first showed that derived neurons exhibited voltage-gated sodium-channel mediated action potentials and received synaptic inputs (Fig
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