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Establishment of K7M2-Luc orthotopic osteosarcoma mouse model and therapeutic effect evaluation Tumor model establishment To establish orthotopic model, K7M2 cells (3 10 6 cells/well) were dispersed in PBS buffer and implanted into right tibia of BALB/c mice

This evidence for lesion heterogeneity is important, as it emphasizes that different lesions may require different treatment strategies to enhance remyelination in some, promoting differentiation may suffice, whereas in others, increasing aOPC numbers will be required

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Sawicka & al

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