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UV and even bright indoor lighting accelerate breakdown when vials are stored in clear glass under standard refrigerator lighting

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It exacerbates acute kidney injury (AKI) by altering gut microbiota and increasing the gut-derived metabolite 3-indoleacrylic acid, which activates neutrophils to release neutrophilic granule protein (NGP), causing renal damage (Dong et al., 2025)

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Activation of the PI3K/Akt pathway upregulates the expression of key osteogenic genes such as Runx2 , ALP , and COL1 , and promotes the synthesis of bone matrix proteins, thereby enhancing osteoblastic function and bone formation ( Additionally, oxidative stress and cellular damage frequently arise within the osteogenic microenvironment, posing challenges to osteoblast survival

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